Can I take zopiclone if I have liver disease?
Zopiclone is metabolised by the liver. Mild to moderate liver disease requires a dose reduction to 3.75mg. Zopiclone should be avoided in severe hepatic impairment (liver failure) because it can precipitate encephalopathy. Always inform your prescriber of any liver condition.
Can I get zopiclone over the counter?
No. Zopiclone is a Prescription-Only Medicine (POM) and a Controlled Drug in the UK. It can only be legally obtained with a valid prescription from a registered UK prescriber. It is illegal to buy zopiclone without a prescription. Avoid unregistered online pharmacies — always check the MHRA register.
How do I know if I am dependent on zopiclone?
Signs include: being unable to sleep without taking zopiclone, significant anxiety if a dose is missed, needing higher doses over time, and feeling unwell (sweating, tremors) when you try to stop. Speak to your GP honestly — they can help you taper safely without judgement.
Can I take zopiclone for jet lag?
Zopiclone is sometimes used for short-term sleep disruption such as jet lag, but it is not licensed for this purpose. If you consider using it for jet lag, discuss with your GP first. Use the minimum effective dose and only on the few nights needed.
Does zopiclone affect kidney function?
Zopiclone is primarily cleared by the liver, with some renal excretion of metabolites. Mild to moderate renal impairment requires a reduced starting dose (3.75mg). Monitor carefully if kidney function is impaired. See the dosage guide.