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Zopiclone · UK information guide

Zopiclone with kidney or liver disease

Why organ function and other medicines affect zopiclone prescribing decisions.

Medical information: This page provides general educational information and is not a substitute for personal medical advice.
Quick answer: Kidney or liver disease can increase sensitivity to sedatives and may change the prescriber’s choice or dose.

Liver disease

Reduced liver function may slow handling of medicines and increase sedation; severe liver disease is an important contraindication or caution.

Kidney disease

Tell the prescriber about kidney disease even though zopiclone is primarily metabolised by the liver.

Older age

Age-related changes can magnify drowsiness, confusion and falls, particularly when organ function is reduced.

Medication review

Provide a complete list of medicines and avoid self-adjusting the dose.

Sources

Draft publication status: This page is prepared for a UK audience but has not yet received qualified clinical review.
Author: MediHarbour Editorial Team · Medical reviewer: To be assigned · Review date: Pending · Draft updated: 1 October 2026.
Sources should be checked against current NHS, MHRA, NICE, UK product information and peer-reviewed evidence before publication. Read our editorial policy.