Zopiclone · Pregnancy and breastfeeding

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Zopiclone in Pregnancy and Breastfeeding: UK Safety Guide

Zopiclone is generally avoided in pregnancy and breastfeeding. Understand the risks, what alternatives exist, and when specialist guidance applies.

✓ UK prescribing context✓ Plain-language answers✓ Linked medical sources
Medical information: This page provides general educational information for people in the UK. It is not a substitute for advice from a qualified healthcare professional.

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02CheckDosage, interactions, side effects and warnings.
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Original productGenuine UK-licensed medicine, supplied through the authorised pharmacy process.
Common usesNerve pain, some seizures and generalised anxiety disorder.
Key cautionDrowsiness and dizziness can affect driving and balance.
Before changing treatmentSpeak with a prescriber before reducing or stopping it.
1
Quick answer: Zopiclone is not licensed for use in pregnancy. Key concerns:Crosses the placenta — can affect foetal brain developmentUse in the third trimester can cause neonatal withdrawal syndrome (tremors, feeding problems, irritability in the newborn)Risk of neonatal respiratory depression.

Risks in pregnancy

Zopiclone is not licensed for use in pregnancy. Key concerns:

  • Crosses the placenta — can affect foetal brain development
  • Use in the third trimester can cause neonatal withdrawal syndrome (tremors, feeding problems, irritability in the newborn)
  • Risk of neonatal respiratory depression if taken close to delivery
  • Data in human pregnancy is limited

Risks during breastfeeding

Zopiclone is excreted into breast milk at concentrations that may sedate a breastfed infant. The BNF advises to avoid zopiclone during breastfeeding. If a single dose is absolutely necessary, feeding should be paused for several hours after the dose. Seek pharmacist or midwife advice.

Safer alternatives for sleep in pregnancy

  • CBT-I (Cognitive Behavioural Therapy for Insomnia) — evidence-based and safe in pregnancy
  • Sleep hygiene optimisation
  • Relaxation techniques and guided mindfulness
  • Addressing underlying anxiety or depression with specialist support

Sources

Additional UK sources

Draft publication status: This page is prepared for a UK audience but has not yet received qualified clinical review.
Author: MediHarbour Editorial Team · Medical reviewer: To be assigned · Review date: Pending · Draft updated: 1 October 2026.
Sources should be checked against current NHS, MHRA, NICE, UK product information and peer-reviewed evidence before publication. Read our editorial policy.